Abstract
Temperature-resolved magnetic particle imaging (MPI) represents a promising tool for medical imaging applications. In this study an approach based on a single calibration measurement was applied for highlighting the potential of MPI for monitoring of temperatures during thermal ablation of liver tumors. For this purpose, liver tissue and liver tumor phantoms embedding different superparamagnetic iron oxide nanoparticles (SPION) were prepared, locally heated up to 70 °C and recorded with MPI. Optimal temperature MPI SPIONs and a corresponding linear model for temperature calculation were determined. The temporal and spatial temperature distributions were compared with infrared (IR) camera results yielding quantitative agreements with a mean absolute deviation of 1 °C despite mismatches in boundary areas.
Highlights
Temperature-resolved magnetic particle imaging (MPI) represents a promising tool for medical imaging applications
We investigate the principle capability of MPI to monitor spatial and temporal temperature distributions in thermal liver tumor ablation therapies
Changes of the measured MPI particle distribution can be directly attributed to temperature changes, since the hepatic superparamagnetic iron oxide nanoparticles (SPION) distribution can be considered quasi-constant after the intravenous SPION injection and hepatic uptake process
Summary
Temperature-resolved magnetic particle imaging (MPI) represents a promising tool for medical imaging applications. Whereas US, fluoroscopy and CT provide fast localization of liver tumor and guidance of ablation devices with adequate image contrast, a real-time measurement of the tissue temperatures induced by the thermal ablation processes is clinically only facilitated by MRI. Magnetic particle imaging (MPI) was initially presented to measure in vivo distributions of superparamagnetic iron oxide nanoparticles (SPION) in cardiovascular applications with high temporal and spatial resolution[7]. The main challenge of thermal tumor ablation represents the tradeoff between sufficient tumor heating – destroying cancer cells reliably – and tolerable heating of healthy adjacent tissue – ensuring liver functionality In this context, MPI can be applied to image the temperature distribution of healthy liver tissue surrounding tumors. In order to evaluate the temperature imaging capabilities of MPI in general and of this application in particular, MPI results of locally heated liver and liver tumor phantoms are compared with optical temperature (OT) sensor and infrared (IR) camera measurements
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