Abstract

Unlike the large number of laboratory experiments on phase-transfer catalysis (PTC) that focus on a catalyzed chemical process, the present laboratory emphasizes the mechanism of phase-transfer catalysis itself. Students can follow visually the actual transfer of the reagent by the catalyst, and its consumption in the organic phase, in a step-by-step process that employs a colored charge-transfer (CT) complex as the transferred reacting species. Consumption of the transferred nucleophile is followed by discoloration of the organic phase. This transfer-consumption cycle can be repeated several times by shaking the two separated phases again, allowing students to finally grasp the whole process as a continuous repetition of these cycles. The experiment also links, through visualization, the important synthetic tool of PTC with abstract concepts based on molecular-orbital and hard–soft acid–base theories, invoked in the formation of a CT complex.

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