Abstract
We present a dual-beam Doppler optical coherence tomography system for visualizing the microvasculature within the retina. The sample arm beams from two identical spectral domain optical coherence tomography (SD-OCT) systems are combined such that there is a small horizontal offset between them at the retina. Thereby we record two tomograms which are slightly separated in time. Phase-resolved Doppler analysis is performed between these two data sets. This system allows blood capillary imaging with high flow sensitivity and variable velocity range. To demonstrate the performance of our system we present images of the microvascular network around the fovea and around the optic nerve head of the human eye.
Highlights
After its first introduction in the 1990s [1], optical coherence tomography (OCT) has found a variety of applications, especially in medical research and ophthalmology [2]
Various different Doppler OCT systems can be found in literature as for example: phase-resolved Doppler OCT (PR-DOCT) [6,7,8], resonant Doppler flow imaging [9], joint spectral and time domain imaging [10], optical micro-angiography (OMAG) [11] or single-pass volumetric bidirectional blood flow imaging (SPFI) [12]
PR-DOCT measures the phase difference between adjacent A-scans, which have to be recorded at overlapping positions within the sample
Summary
After its first introduction in the 1990s [1], optical coherence tomography (OCT) has found a variety of applications, especially in medical research and ophthalmology [2]. Various different Doppler OCT systems can be found in literature as for example: phase-resolved Doppler OCT (PR-DOCT) [6,7,8], resonant Doppler flow imaging [9], joint spectral and time domain imaging [10], optical micro-angiography (OMAG) [11] or single-pass volumetric bidirectional blood flow imaging (SPFI) [12]. PR-DOCT measures the phase difference between adjacent A-scans, which have to be recorded at overlapping positions within the sample. This phase difference Δ is directly proportional to the velocity of the moving particle:
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