Abstract
A chemosensor, 3-aminophenol-based rhodamine conjugate (ARC) has been developed for visualisation of diethylchlorophosphate (DCP), mimic of a chemical warfare agent, in Catfish brain. The simple detection of DCP by “turn-on” fluorescence property of the chemosensor makes it unique for easy and rapid in vivo and in vitro detection of DCP with the detection limit of 5.6 nM.
Highlights
1995, The terrorist attack on Tokyo subway introduces the whole world with a new threat to mankind- Chemical Warfare Agents (CWAs)[1,2,3]
Several detection methods, such as- colorimetry[7,8,9,10], fluorometry[11,12,13,14,15,16,17], interferometry[18], electrochemistry[19,20,21,22], surface acoustic wave (SAW) devices[23,24], photoacoustic spectroscopy[25], moleculer imprinting coupled with lanthanide luminescence and fibre optics[26,27,28], enzymatic assay[29,30], and gas chromatography-mass spectrometry[31] have been explored to detect substantial number of CWAs
Probe aminophenol-based rhodamine conjugate (ARC) was synthesized from a simple reaction of rhodamine B and POCl3, followed by reaction with 3-amino phenol with 74% overall yield
Summary
1995, The terrorist attack on Tokyo subway introduces the whole world with a new threat to mankind- Chemical Warfare Agents (CWAs)[1,2,3]. The chemosensors mediated detection is an extremely convenient and simple method based on optical outputs such as color change or change in fluorescence intensity after the exposure to the target analytes[32,33,34,35] Chemosensors make such detection method attractive and widely acceptable by fulfilling the key features of a practical sensing system i.e. high selectivity, sensitivity, specificity, portability, ability of real time sensing along with cost effectiveness[36,37]. DCP is much less toxic than Sarin but its mode of action is similar With this stand point in this particular research field, we have described a chemosensor ARC, 3-aminophenol based rhodamine conjugate. As per our knowledge this is the first report where a chemosensor is used for visualizing DCP in vivo
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