Visual motion processing deficits in infants with the fragile X premutation.

Pamela K Gallego,Jessica L Burris,Susan M Rivera

doi:10.1186/1866-1955-6-29

Abstract

BackgroundFragile X syndrome (FXS) results from a trinucleotide repeat expansion (full mutation >200 cytosine-guanine-guanine (CGG) repeats) in the FMR1 gene, leading to a reduction or absence of the gene’s protein product, fragile X mental retardation protein (FMRP), ultimately causing cognitive and behavioral impairments that are characteristic of the syndrome. In our previous work with infants and toddlers with FXS, we have been able to describe much about their cognitive and visual processing abilities. In light of recent work on the mild cognitive deficits and functional and structural brain differences that are present in adults with the fragile X (FX) premutation, in the present study we examined whether some of the low-level visual processing deficits we have observed in infants with FXS would also be present in infants with the FX premutation (55–200 CGG repeats).MethodsWe chose a contrast detection task using second-order motion stimuli on which infants with FXS previously showed significantly increased detection thresholds (Vision Res 48:1471–1478, 2008). Critically, we also included a developmental delay comparison group of infants with Down syndrome (DS), who were matched to infants with FXS on both chronological and mental age, to speak to the question of whether this second-order motion processing deficit is a FX-specific phenomenon.ResultsAs reported previously, infants with the FX full mutation showed motion contrast detection threshold levels that were significantly higher than age-matched typically developing control infants. Strikingly, the motion detection contrast levels of FX premutation infants were also significantly higher than typically developing (TD) infants and not significantly different from the group of infants with FXS or with DS.ConclusionsThese results, which are in keeping with a growing body of evidence on the mild cognitive and perceptual processing deficits and functional and structural brain differences that are present in adults and older children with the FX premutation, underscore the pressing need to study and describe the processing capabilities of infants and toddlers with the FX premutation.

Highlights

Fragile X syndrome (FXS) results from a trinucleotide repeat expansion (full mutation >200 cytosine-guanine-guanine (CGG) repeats) in the FMR1 gene, leading to a reduction or absence of the gene’s protein product, fragile X mental retardation protein (FMRP), causing cognitive and behavioral impairments that are characteristic of the syndrome
Fragile X syndrome (FXS) is the most common inherited cause of mental disability, which results from a reduction or absence of the fragile X mental retardation protein (FMRP), a gene product known to play an essential role in brain structure and function [1,2]
Recent work on the mild cognitive deficits and functional and structural brain differences that are present in adults with the FX premutation [7,8,10,11,26] and studies which have documented deficits in visuospatial [27,28] and contrast sensitivity [29] in adult premutation carriers led us in the present study to examine whether one of the low-level visual processing deficits that has been observed in infants with FXS is present in infants with the FX premutation

Summary

Introduction

Fragile X syndrome (FXS) results from a trinucleotide repeat expansion (full mutation >200 cytosine-guanine-guanine (CGG) repeats) in the FMR1 gene, leading to a reduction or absence of the gene’s protein product, fragile X mental retardation protein (FMRP), causing cognitive and behavioral impairments that are characteristic of the syndrome. Fragile X syndrome (FXS) is the most common inherited cause of mental disability, which results from a reduction or absence of the fragile X mental retardation protein (FMRP), a gene product known to play an essential role in brain structure and function [1,2]. This condition emerges when the repeat expansion of the trinucleotide. Because of its relatively protracted time course of development [24], the dorsal stream is thought to be vulnerable to atypical development in a number of disorders, including in FXS [16,25]

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