Visual mismatch: Some applications in pharmacology, pathology, and development

Abstract

Event Abstract Back to Event Visual mismatch: Some applications in pharmacology, pathology, and development J. L. Kenemans1* 1 Experimental Psychology and Psychopharmacology,Utrecht University, Netherlands A number of reports have documented detrimental effects of moderate alcohol (BAC of about 0.05 %) on the Mismatch Negativity (MMN), the electro-cortical manifestation of a rapid (100 ms post-stimulus) mechanism dedicated to the detection of unexpected auditory change Analogous to the aMMN, a visual Mismatch or Rareness-Related Negativity (vMMN or RRN) evolves at about 100 ms after the unexpected change, and has been localized in visual cortex. Rapid detection of unexpected events is important for everyday-life conditions like driving, prompting the question whether the visual RRN shows sensitivity to moderate alcohol similar to the MMN. In one study, alcohol effects on aMMN as reported before were replicated, and the RRN, defined as the difference between deviant and standard ERPs between 120 and 170 ms at Oz, was present under placebo, but not under alcohol. Thus, moderate alcohol impairs the rapid detection in visual cortex of unexpected changes. One possibility is that alcohol interferes with cholinergic transmission in visual cortex, which has been suggested to sustain selection of relevant visual information and attentional capture by salient events. This notion may be consistent with the reported reduction of vMMN in schizophrenia, but would not predict the reduced vMMN with normal aging, nor the increase with chronic methamphetamine abuse, and seems to be at odds with the increased vMMN as observed in Alzheimer’s Disease. Other biochemical mechanisms may therefore be instrumental, perhaps generally mediated by adenosine agonism. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Oral Presentation Topic: Workshop 1: Visual Mismatch Negativity (vMMN) Citation: Kenemans JL (2009). Visual mismatch: Some applications in pharmacology, pathology, and development. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.010 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Mar 2009; Published Online: 19 Mar 2009. * Correspondence: J. L Kenemans, Experimental Psychology and Psychopharmacology,Utrecht University, Utrecht, Netherlands, j.l.kenemans@uu.nl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers J. L Kenemans Google J. L Kenemans Google Scholar J. L Kenemans PubMed J. L Kenemans Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.