Abstract
In Parkinsonism, visual hallucinations (VH) and REM sleep behavior disorder (RBD) have been thought to indicate underlying synucleinopathy. We tested the validity of this hypothesis by searching for VH and RBD symptoms in Parkinsonism related to tauopathies. Patients with progressive supranuclear palsy or corticobasal degeneration were identified via a clinical data bank. Of 53 patients who expressed study interest by telephone, 44 returned questionnaires. VH occurred in 16% of patients. Similarly, acting out of dreams occurred in 16% of patients. Neither VH nor RBD symptoms were linked to disease duration or dopaminergic medication and there was no mutual association. VH and RBD symptoms also occur in Parkinsonism related to tauopathies, thus refuting the initial hypothesis.
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