Abstract
The purpose of this study was to investigate the structure-function relationship between BMO-MRA and VF in patients with open-angle glaucoma. We retrospectively reviewed 67 eyes of 50 patients with open-angle glaucoma who underwent spectral-domain optical coherence tomography for BMO-MRA and the Humphrey VF test. BMO-MRA of the glaucomatous optic nerve head was divided into 12 sectors. The correlation between BMO-MRA sectors and the VF points was analyzed to generate a new VF cluster map. Forty-three of the 52 VF points showed a significant correlation with at least 1 BMO-MRA sector. The VF cluster map was generated using the BMO-MRA sectors and each VF point that showed the most correlation. The superior hemifield correlated with 5, 6, 7, and 8 o'clock positions (ρ=0.312 to 0.710), whereas the inferior hemifield correlated with 10, 11, 12, and 2 o'clock positions (ρ=0.241 to 0.483). The VF cluster maps of superior and inferior hemifields showed different configurations of VF clusters and topographical relationships with the glaucomatous optic nerve head. The newly generated VF cluster map corresponding to BMO-MRA sectors showed a significant structure-function relationship and could be useful in the diagnosis and evaluation of glaucoma.
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