Abstract
AbstractThe visual evoked potential (VEP) to a flash stimulus proved to be more effective than quantitative perimetry in detecting evidence of previous optic neuritis (97 vs 56%) or asymptomatic lesions in the visual pathways (56 vs 14%) of 49 patients with multiple sclerosis. The characteristic VEP abnormality, increased latency, was also found in 8 of 15 eyes with visual field defects related to ischemic optic neuropathy. This abnormality therefore is not specific for demyelinative disease, but it is highly suggestive in the presence of normal visual function determined psychophysically. The VEP disclosed a high incidence (81%) of asymptomatic lesions in optic nerves opposite previously affected eyes. Neither the presence nor the magnitude of the latency abnormality correlated with the degree of visual impairment. Prolonged latency may not be present at the onset of acute optic neuritis.
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