Abstract
It was well documented that both the size of the dendritic field and receptive field of retinal ganglion cells (RGCs) are developmentally regulated in the mammalian retina, and visual stimulation is required for the maturation of the dendritic and receptive fields of mouse RGCs. However, it is not clear whether the developmental changes of the RGC receptive field correlate with the dendritic field and whether visual stimulation regulates the maturation of the dendritic field and receptive field of RGCs in a correlated manner. The present work demonstrated that both the dendritic and receptive fields of RGCs continuously develop after eye opening. However, the correlation between the developmental changes in the receptive field size and the dendritic field varies among different RGC types. These results suggest a continuous change of synaptic converging of RGC synaptic inputs in an RGC type-dependent manner. Besides, light deprivation impairs both the development of dendritic and receptive fields.
Highlights
Retinal ganglion cells (RGCs) receive visual information from bipolar cells (BCs) and amacrine cells (ACs) and convey the visual information to higher centers of the visual system
We first quantify the size of mouse retinal ganglion cells (RGCs) dendritic field changes during development after eye opening
The sizes of RGC ON and OFF dendritic field were determined based on stacked fluorescent images of Thy1-yellow fluorescent protein (YFP)+ RGCs, which were collected with a confocal microscope, from ON or OFF sublamina in the IPL
Summary
Retinal ganglion cells (RGCs) receive visual information from bipolar cells (BCs) and amacrine cells (ACs) and convey the visual information to higher centers of the visual system. The dendrites of RGCs are stratified into ON or OFF sublamina of the inner plexiform layer (IPL) of the retina to synapse with ON or OFF BCs, respectively This dendritic segregation of RGCs in the IPL ensures the ON and OFF RGCs respond to increment or decrement of light stimulation, respectively. Previous studies demonstrated that many morphological and functional properties of RGCs continue to develop after the retina responds to light stimulation. These include the size of dendritic fields (Ren et al, 2010; Qu and Myhr, 2011; Elias et al, 2018), dendritic segregation into ON and OFF layers of the IPL (Tian and Copenhagen, 2003), light-evoked synaptic activity
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