Visual Deprivation Alters Functional Connectivity of Neural Networks for Voice Recognition: A Resting-State fMRI Study

Abstract

Humans recognize one another by identifying their voices and faces. For sighted people, the integration of voice and face signals in corresponding brain networks plays an important role in facilitating the process. However, individuals with vision loss primarily resort to voice cues to recognize a person's identity. It remains unclear how the neural systems for voice recognition reorganize in the blind. In the present study, we collected behavioral and resting-state fMRI data from 20 early blind (5 females; mean age = 22.6 years) and 22 sighted control (7 females; mean age = 23.7 years) individuals. We aimed to investigate the alterations in the resting-state functional connectivity (FC) among the voice- and face-sensitive areas in blind subjects in comparison with controls. We found that the intranetwork connections among voice-sensitive areas, including amygdala-posterior "temporal voice areas" (TVAp), amygdala-anterior "temporal voice areas" (TVAa), and amygdala-inferior frontal gyrus (IFG) were enhanced in the early blind. The blind group also showed increased FCs of "fusiform face area" (FFA)-IFG and "occipital face area" (OFA)-IFG but decreased FCs between the face-sensitive areas (i.e., FFA and OFA) and TVAa. Moreover, the voice-recognition accuracy was positively related to the strength of TVAp-FFA in the sighted, and the strength of amygdala-FFA in the blind. These findings indicate that visual deprivation shapes functional connectivity by increasing the intranetwork connections among voice-sensitive areas while decreasing the internetwork connections between the voice- and face-sensitive areas. Moreover, the face-sensitive areas are still involved in the voice-recognition process in blind individuals through pathways such as the subcortical-occipital or occipitofrontal connections, which may benefit the visually impaired greatly during voice processing.