Abstract
Human adults with normal vision can combine visual landmark and non-visual self-motion cues to improve their navigational precision. Here we asked whether blind individuals treated with a retinal prosthesis could also benefit from using the resultant new visual signal together with non-visual information when navigating. Four patients (blind for 15-52 years) implanted with the Argus II retinal prosthesis (Second Sight Medical Products Inc. Sylmar, CA), and five age-matched and six younger controls, participated. Participants completed a path reproduction and a triangle completion navigation task, using either an indirect visual landmark and non-visual self-motion cues or non-visual self-motion cues only. Control participants wore goggles that approximated the field of view and the resolution of the Argus II prosthesis. In both tasks, control participants showed better precision when navigating with reduced vision, compared to without vision. Patients, however, did not show similar improvements when navigating with the prosthesis in the path reproduction task, but two patients did show improvements in the triangle completion task. Additionally, all patients showed greater precision than controls in both tasks when navigating without vision. These results indicate that the Argus II retinal prosthesis may not provide sufficiently reliable visual information to improve the precision of patients on tasks, for which they have learnt to rely on non-visual senses.
Highlights
During navigation, humans with healthy vision rely on both visual and non-visual sensory information to update their position and orientation within their environment
In this study we examine whether blind patients, implanted with the Argus II retinal prosthesis, are able to use this new visual signal together with non-visual information, to improve their performance on two well-known navigation tasks: a path reproduction and a triangle completion task
This study assessed whether patients implanted with the Argus II retinal prosthesis would use this new visual signal to improve navigational precision, by using spatial information provided by an indirect visual landmark as well as non-visual self-motion cues
Summary
Humans with healthy vision rely on both visual and non-visual sensory information to update their position and orientation within their environment. Research has documented enhanced perception by non-visual modalities for certain tasks following blindness, including tactile discrimination [12, 13], spatial sound localization [14, 15] and spatial route learning [16]. This improvement in the reliability of non-visual processing has been linked to crossmodal neural reorganisation, with studies showing non-visual recruitment of the occipital cortex in the blind (e.g. review by [17, 18]). Such compensatory plasticity has implications for treatments that aim to restore vision by stimulating the deprived visual system directly, such as retinal prostheses
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