Abstract
AbstractAn efficient photocatalytic regioselective difluoroalkylation of 8‐aminoquinolines at the C‐5 position via a debrominative coupling reaction with difluoromethyl bromides has been developed. A series of 8‐aminoquinolines amides proved to be tolerated for this transformation, affording a variety of 5‐difluoromethylated quinoline derivatives in moderate to excellent yields. This protocol was highlighted by its readily available starting materials, wide functional group tolerance, operational simplicity, and mild conditions.
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