Abstract
This study aimed at evaluating the visible light mediated antimicrobial and osteogenic applications of noble metal, such as gold (Au) and platinum (Pt) coated titania (TiO2) nanotubes (NTs). In this study, the Au and Pt nanoparticles (NPs) were deposited on anodized 100 nm TiO2 NTs by ion plasma sputtering. The Au and Pt NPs were mainly deposited on the top surface layer of TiO2 NTs and showed light absorbance peaks around the 470 and 600 nm visible light region used in this study, as seen from the surface characterization. From the results of antibacterial activity test, Au and Pt NPs that were deposited on TiO2 NTs showed excellent antibacterial activity under 470 nm visible light irradiation due to the plasmonic photocatalysis based on the localized surface plasmon resonance effect of the Au and Pt NPs. In addition, alkaline phosphate activity test and quantitative real-time PCR assay of osteogenic related genes resulted that these NPs promoted the osteogenic functionality of human mesenchymal stem cells (hMSCs) under 600 nm visible light irradiation, because of the synergic effect of the photothermal scattering of noble metal nanoparticles and visible light low-level laser therapy (LLLT). Therefore, the combination of noble metal coated TiO2 NTs and visible light irradiation would be expected to perform permanent antibacterial activity without the need of an antibacterial agent besides promoting osteogenic functionality.
Highlights
The success of an implant has been linked to functional aspects related to mastication and pronunciation; tissue physiological aspects, including excellent osseointegration without inflammation, and psychological aspects that satisfy aesthetics without causing pain or discomfort [1]
The absorbance peak around 450–500 nm is supposedly due to plasmonic photocatalysis from the localized surface plasmon resonance (LSPR) effect of Au and Pt NPs deposited on TiO2 NTs
The Au and plasmonic photocatalysis from the LSPR effect of Au and Pt NPs deposited on TiO2 NTs
Summary
The success of an implant has been linked to functional aspects related to mastication and pronunciation; tissue physiological aspects, including excellent osseointegration without inflammation, and psychological aspects that satisfy aesthetics without causing pain or discomfort [1] From this point of view, an implant would be a total failure if it fails to achieve functions and aesthetics for various reasons, such as material degradation, bacterial infection, improper osseointegration, and so on [2]. Alternative treatments without antibacterial agents, such as antimicrobial polymers [8], antibacterial Ag nanoparticles (NPs) [9,10], photodynamic therapy [11], and photocatalysis of titania (TiO2 ) [12,13,14] have been introduced due to increased multi-drug resistance of bacterial strains Among these treatments, the photocatalytic antibacterial effect of TiO2 is expected to be very useful, since dental implants and medical implantable devices mainly use titania or titania alloy
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
