Abstract
Effective regulation of cell-surface interactions is critical for regenerative medicine and other cell-based therapies. Herein, visible-light-induced cell sheet harvesting based on silicon wafers with a p/n junction [Si(p/n)] is introduced. Cell sheets could quickly detach from the Si(p/n) surface after 10 min of visible-light illumination with maintained cell viability and functions. It is found that preadsorbed proteins on the Si(p/n) surface like BSA and collagen-I show light-induced desorption behaviors. Molecular dynamics simulation also indicates that long-range force caused by the photovoltaic effect of Si(p/n) under visible-light illumination plays a key role in triggering the release of the preadsorbed protein. It is suggested that such protein desorption behavior mediated by the photovoltaic effect is responsible for cell release. This work not only shows promising potential for cell sheet harvesting, but also provides new insights into protein-material interactions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.