Abstract
AbstractA visible‐light‐promoted radical fluoroalkylation has been achieved through a three‐component reaction of fluoroalkyl reagents, isocyanides and water, affording fluoroalkyl‐substituted amides in good yields. This reaction involves the generation of the nitrilium cation by single‐electron reduction of the imidoyl radical and a subsequent nucleophilic attack by water. Mechanistic studies support the generation of the imidoyl radical through the capture of the fluoroalkyl‐substituted imidoyl radical species.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have