Abstract
We report a one-step procedure to selectively reduce secondary and tert-amides to their corresponding amine derivatives in the presence of an ester. This was achieved via the synergistic combination of a photoredox, a nickel catalytic system, and phenyl silane as a reductant in the presence of blue light-emitting diode light (455 nm) at room temperature. Further, this mild light-promoted dual metallaphotoredox catalytic system was also successful in selectively reducing a lactam to the cyclic amines, without affecting the ester moiety present in the molecules.
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