Visible Light‐Mediated Defluorination to Access 1,1‐Difluoro‐1,3‐Enynes

Abstract

Herein, a visible light‐mediated defluorination reaction to access 1,1‐difluoro‐1,3‐enynes is described. Compared with previous studies, this protocol employs more readily accessible acids as a radical precursor under the redox‐neutral conditions. Moreover, the reaction exhibits high compatibility with diverse primary, secondary and tertiary acids, especially natural amino acids and drug‐derived acids. Preliminary mechanism investigations reveal that a radical pathway is involved in the catalytic cycle.