Visible-light-induced cascade radical cyclization for the synthesis of amide-functionalized fused quinazolinones

Abstract

A light-induced non-activated olefin cascade radical addition/cyclization reaction was proposed, leading to the successful synthesis of 39 quinazolinone derivatives containing amide moieties, with yields up to 88 %. The reaction mechanism was studied by radical strapping test and DFT methods, verifying an oxidative-triggered cascade process promoted by the acylamino radicals. This strategy features mild conditions and broad substrate compatibility, providing a high atom-economical synthesis method for diverse quinazolinone.