Abstract
Infection is one of several factors that can delay normal wound healing. Antibacterial wound dressings can therefore promote normal wound healing. In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD)/triclosan (TCS) complex (CD-ic-TCS), and evaluated its wound healing effects in vivo. The 1H NMR spectra of ColMA and CD-ic-TCS revealed characteristic peaks at 1.73, 5.55, 5.94, 6.43, 6.64, 6.84, 6.95, 7.31, and 7.55 ppm, indicating successful preparation of the two material types. In addition, ultraviolet–visible (UV–vis) spectroscopy proved an inclusion complex formation between HP-β-CD and TCS, judging by a unique peak observed at 280 cm−1. Furthermore, ColMA/CD-ic-TCS exhibited an interconnected porous structure, controlled release of TCS, good biocompatibility, and antibacterial activity. By in vivo animal testing, we found that ColMA/CD-ic-TCS had a superior wound healing capacity, compared to the other hydrocolloids evaluated, due to synergistic interaction between ColMA and CD-ic-TCS. Together, our findings indicate that ColMA/CD-ic-TCS has a clinical potential as an antibacterial wound dressing.
Highlights
Licensee MDPI, Basel, Switzerland.Wound dressings are widely used to protect the wound bed and accelerate wound healing [1]
We evaluated the wound healing efficacy of a novel type of antimicrobial dressing agent based on a visible light-cured methacrylated collagen hydrogel containing a betacyclodextrin/triclosan inclusion complex (ColMA/CD-ic-TCS) using a mouse skin defect model (Figure 1)
The inclusion complex between HP-β-CD and TCS and the chemical reaction between collagen and MA were characterized by 1 H NMR analysis using D2 O (Figure 2)
Summary
Licensee MDPI, Basel, Switzerland.Wound dressings are widely used to protect the wound bed and accelerate wound healing [1]. The ideal wound dressing should be non-toxic, have suitable viscosity and mechanical properties, and be able to absorb exudate, prevent bacterial infections, and maintain humidity around the wound [2]. Hydrogels have many of the properties listed above and can accelerate wound healing [3]. The three-dimensional structure of hydrogels enables them to retain water molecules and to provide a moist wound bed environment. This allows for proper cell adhesion and proliferation and thereby accelerates wound healing [4,5]. Have some disadvantageous mechanical and pharmacokinetic properties They lack affinity for cells, which is needed for wound healing [9,10]. Various types of collagen hydrogels prepared by physicochemical crosslinking have been introduced, but the relatively high toxicity of the crosslinkers used has limited their biomedical applications [14]
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