Abstract
Background: Adipose tissues produce adipocytokines and other various substances that have useful actions in the body. One of such adipocytokines is visfatin which has been linked to diabetes mellitus. Aim: This study aimed at investigating the existence of a probable correlation between plasma levels of visfatin and the various types of diabetes mellitus: type 1, type 2 and gestational diabetes mellitus. Methods: A comprehensive literature search was performed using the Internet search engines linked to academic databases including Pubmed, Google Scholar, Ebsco, Hinari, etc. Studies involving visfatin were thoroughly searched and the references of such articles were also searched for any probable relevant information. Results/Findings: There is no agreed finding regarding the correlation between visfatin and diabetes mellitus. While some authors believed that plasma visfatin levels are elevated in diabetes mellitus, others believed that the contrary might be true. Conclusion: Various studies conducted so far have contrasting opinions about the correlation between plasma visfatin levels and diabetes mellitus.
Highlights
Adipose tissue has been widely studied and it is currently recognized as an endocrine organ that produces adipocytokines that have different effects on body metabolic processes [1,2]
Ahmed et al studied 116 subjects with type 2 diabetes mellitus and found that plasma visfatin levels were significantly higher in diabetic patients than in the healthy control group (P0.005)
Chen et al studied 61 patients with type 2 diabetes mellitus and 59 non-diabetic controls of similar sex and age. They found that plasma visfatin was elevated in the patients with type 2 diabetes when compared to the controls (P=0.002)
Summary
Adipose tissue has been widely studied and it is currently recognized as an endocrine organ that produces adipocytokines that have different effects on body metabolic processes [1,2]. Hontzch et al studied 124 patients with type 1 diabetes, and found that visfatin levels were higher in the adolescent and children with type 1 diabetes than the control group They even suggested an influence on glucose metabolism in insulin-deficient patients, independent from body mass index [41]. Ahmed et al studied 116 subjects with type 2 diabetes mellitus and found that plasma visfatin levels were significantly higher in diabetic patients than in the healthy control group (P0.005). Osama et al studied 80 people with type 2 diabetes mellitus and a control group They aimed at finding a link between plasma levels of visfatin and type 2diabetes patients. This was further supported by a significant association between visfatin and insulin resistance [3]
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