Visfatin and Correlated Clinical parameters in Type 2 Diabetes Mellitus as Diagnostic Factor in Osteoarthritis Patients in Sulaimani, Iraq

Abstract

It was proved that neuropathy caused by impaired glucose tolerance / diabetes mellitus inhibits the expressionof pain due to osteoarthritis in the lower extremities among a portion of patients displaying radiographicosteoarthritis. Both osteoarthritis and DM can be viewed as chronic disease processes characterized byearl, undetected levels of biological change. This study was carried out to investigate serum visfatin andcorrelated to parameters in osteoarthritis patients. Sixty-eight patients suffering from Diabetes Mellitus andosteoarthritis are involved in the study for investigating the role of visfatin and related clinical markers in thecases studied. Twenty healthy controlled volunteers were used for comparing obtained results. Specific kitswere used for the determination of visfatin and related parameters. The results of the study were revealedincreases in the levels of visfatin, glucose, HbA1c, and insulin resistant. The only decreases were found inthe insulin levels. It seems that visfatin has been proved to have a physiological influence in osteoarthritis isPatients suffers from type II diabetes mellitus.