Abstract
Visfatin is an important adipokine with various roles in cell metabolic functions. Visfatin might play a role in the regulation of food intake, but its potential effects on energy metabolism and thermogenesis have not been well documented so far. Brown adipose tissue (BAT) has been the focus of studies on metabolism in the last decades. Recent studies have shown a relationship between visfatin with BAT differentiation and function. It has been shown that visfatin levels increased in brown adipocytes following differentiation, and visfatin mRNA expression was significantly higher in BAT than white adipose tissue. Additionally, this adipokine could increase uncoupling protein-1 (UCP-1) level in BAT and modulate the expression of major genes involved in BAT thermogenesis. Further studies are required to understand the probable role of visfatin as a marker, a mediator, or an inducer of BAT activity, and its potential clinical and therapeutic value in metabolic disorders.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
