Abstract
High viscosity is important for normal intracellular homeostasis. In this study, nanoporous drug delivery systems (DDSs), including mesoporous silica nanoparticles (MSNs) and layer by layer (LBL) microcapsules, with a viscosity enhanced release (VER) effect were designed and prepared, and their drug release behaviors in a sticky environment with a high viscosity were investigated using rhodamine B, methylene blue and doxorubicin (DOX) as model drugs. The results showed that the drug release rate from DDSs in a biomimetic high viscosity solution was 7 to 8 times higher than that in water. A semipermeable membrane model was used to explain the VER effect. The results indicate that the existence of macromolecules in the release medium caused a VER effect. The VER effect found in this study will provide a new concept to guide the design of DDSs in a high viscosity environment in vivo.
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