Abstract
Abstract A series of flavonoids were isolated from Dodonaea Viscosa and tested for inhibition of human neutrophil elastase (HNE), enzyme involved in inflammatory disorders. Isolated compounds were identified as a novel flavonol ( 1 ) along with eight known flavonoids ( 2 – 9 ). Novel flavonol, visconata ( 1 ) has a very rare skeleton having odd numbered long chain (C19) fatty acid, which was completely identified by mass fragmentation and 2D NMR analysis. All compounds ( 1 – 9 ) inhibited HNE in dose dependent manner with IC 50 s ranging between 2.4 and 150 μM. Visconata ( 1 ) emerged to be the most potent compound with 2.4 μM of IC 50 . In kinetic studies, compound ( 1 ) was observed to be reversible, noncompetitive inhibitor having K i = 1.8 μM, whereas other flavonoids ( 2 – 9 ) displayed mixed type inhibition.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
