Abstract
Colloid chemical behavior of indole dihydropyrimidines in non-aqueous solvent mixture benzene-methanol of varying composition has been investigated by viscometric measurements at 303K± 0.1. The viscosity of the system increases with the increase in concentration. The Trend Change Point (TCP) values have been determined by intersection of two straight lines, which are found to be dependent on the composition of solvent mixtures. The study confirms that the nature of synthesized compounds agglomerate formed below and above 50% benzene concentration is quite different. The viscometric data have been analyzed in terms of Einstein, Vand, Moulik and Jones-Dole equations. These well known equations have been successfully applied to explain the results of viscosity measurements and the viscometric parameters show that the behavior of compound changes in the proximity of 50% benzene concentration.
Highlights
In the family of heterocyclic compounds Nitrogen containing heterocycles are an important class of compounds in the medicinal chemistry and contributed to the society from biological and industrial point which helps to understand life processes.[1]
The interest focused on Biginelli compounds leading to the development of Nitractin, 3 that has excellent activity against the virus of trachoma group, the same compounds exhibit antibacterial activity. 4-Aryl dihydropyrimidines e.g. Nifedipine are the important and most studied class as Calcium channel modulars, in 1975 their introduction in clinical medicine for the treatment of cardiovascular diseases.[4] some of the analogues were screened as antitumor agents
The viscosity data based on various equations has been extensively used to furnish information concerning the structural changes in solution trend change point (TCP) and nature of molecule-solvent interaction
Summary
In the family of heterocyclic compounds Nitrogen containing heterocycles are an important class of compounds in the medicinal chemistry and contributed to the society from biological and industrial point which helps to understand life processes.[1]. Artigo Article ducts act as cytotoxic and antifungal compounds belongs to class noprtopsentins.[7] The presence of highly substituted indole and indolines in a variety of bioactive molecular targets has inspired a number of groups including ours to develop new and improved routes to their synthesis.[8] Recently there is a much interest in the synthesis of small molecules for chemist in accelerating drug discovery.[9]. The viscosity data based on various equations has been extensively used to furnish information concerning the structural changes in solution trend change point (TCP) and nature of molecule-solvent interaction. This vital information plays an important role in their selection for various industrial and biological applications.
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