Abstract
Recently, the author read a few published medical articles regarding pancreatic cancer (PC) and will outline some key information in the Introduction section. “Insulin resistance is an interrupted state in the biological response to insulin. It is reported that chronic hyperinsulinemia is associated with various types of cancer such as colorectal cancer, pancreatic cancer, endometrial cancer, and breast cancer (Reference 1). Symptoms of Insulin Resistance: Some signs of insulin resistance include a waistline over 40 inches in men and 35 inches in women; blood pressure readings of 130/80 or higher; and fasting glucose level over 100 mg/dL (Reference 2). (Note from the author: he had all of the above biomarker readings in 2010.) PC is a common cause of cancer-related death, due to difficulties in detecting early-stage disease, its aggressive behavior, and poor response to systemic therapy. Therefore, developing strategies for early diagnosis of resectable PC is critical for improving survival. Diabetes mellitus is another major public health problem worldwide. Furthermore, diabetes can represent both a risk factor and a consequence of PC: nowadays, the relationship between these two diseases is considered a high priority for research (Reference 3). Since its initial recognition in the 20th century, Pancreatic Cancer has always been considered a virtually incurable disease; likewise, the prognosis has not changed much in recent years, compounded by a worldwide increase in incidence [1,2]. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common malignancy of the exocrine pancreas, accounting for > 90% of cases, with a very poor prognosis. In this review, we will focus exclusively on PDAC. Increasing evidence indicates the presence of a pathological link between obesity, diabetes, and PDAC (Reference 4).
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