Visceral Fat-associated Adipokines and Metabolic Variables in Central Obese Type 2 Diabetic Patients

Abstract

aims: The aim of the study was to comprehend the relationship between visceral fat-associated adipokines and biochemical variables in central obese type 2 diabetic patients. background: Visceral obesity is linked with insulin resistance in peripheral tissues and is an alternative risk determinant for developing type 2 diabetes mellitus. The infiltration of macrophages in the visceral fatty tissue and the unreliable generation of adipokines are associated with mechanisms directing the progress of insulin resistance. objective: The objective of the study was to evaluate the relationship between visceral fat-associated adipokines and biochemical variables in central obese type 2 diabetic patients. method: Serum adipokines were analyzed by Eenzyme-Linked Immunosorbent Assay. Biochemical variables were measured using Cobas® 6000 analyzer. HbA1c was measured by High Performance Liquid Chromatography. result: The results show a significant relationship (p < 0.05) between the adipokines and Fasting Plasma Glucose (FPG), Postprandial Blood Glucose (PPBG) and HbA1c levels. The results indicate a significant association (p < 0.05) between the adipokines and lipid profile with varying degrees in central obese type 2 diabetic subjects. conclusion: The relationship between visceral fat-associated adipokines and metabolic variables may influence the metabolic pathways in central obese type 2 diabetic patients. The adipokines are strong predictors for the intensification of type 2 diabetes mellitus and can be used as a diagnostic tool for risk assessment in the central obese population. other: The study provides new insight that requires further investigations and understanding of the metabolic pathways in central obese type 2 diabetic patients.