Visceral adiposity index score indicated the severity of coronary heart disease in Chinese adults.

Lu Han,Meng-Xiong Tang,Ming Zhong,Zhi-Hao Wang,Kai-Li Fu,Yun Zhang,Wei Zhang,Jia Wang,Hui Wang,Jing Zhao

doi:10.1186/1758-5996-6-143

Lu Han, Meng-Xiong Tang + Show 8 more

Open Access

https://doi.org/10.1186/1758-5996-6-143

Copy DOI

Abstract

BackgroundVisceral adiposity contributes to cardiometabolic risk, and visceral adiposity index (VAI) had significant correlation with visceral adiposity. We aimed to explore whether VAI was associated with cardiac structure and function and assess the impact of the cut-off points of VAI defining visceral adipose dysfunction (VAD) on the severity of coronary heart disease (CHD).MethodsA total of 95 patients with CHD were divided into Control (nondiabetic CHD patients) and DM group (diabetic CHD patients). Then the two groups were respectively divided into VAD absent and VAD groups. Clinical, echocardiographic and coronary artery angiographic indexes were acquired to examine in relation to VAI.ResultsA significant increasing trend among the four groups of patients (Control + VAD absent, Control +VAD, DM + VAD absent and DM +VAD groups) were observed for waist circumference (WC), body mass index (BMI), systolic blood pressure (SBP), glucose, VAI and Gensini score (P<0.05 for all). The following variables were associated with VAI: total cholesterol, nonesterified fatty acid, Waist-Hip ratio and SBP. VAI was independently associated with Gensini score.ConclusionsThe extent of CHD was more severe in diabetes, and VAI as a simple indicator of visceral adipose mass was strongly associated with the severity of CHD. The cut-off points of VAI used for defining VAD were more useful in diabetic CHD patients in identifying the severity of CHD.

Highlights

Visceral adiposity contributes to cardiometabolic risk, and visceral adiposity index (VAI) had significant correlation with visceral adiposity
DM group had significantly higher body weight, waist circumference (WC), Waist-Hip ratio, systolic blood pressure (SBP), body mass index (BMI), fasting glucose, total cholesterol (TC), TG, nonesterified fatty acid (NEFA) and Gensini score and lower high-density lipoprotein (HDL) which showed that diabetes mellius had more serious glucose metabolic disorders, dyslipidemia and coronary lesion
The major findings of the present study lead us to the following conclusions: [1] The coronary heart disease (CHD) patients without diabetes had no significant differences in glucose and lipid metabolism disorders between visceral adipose dysfunction (VAD) absent group and VAD group, but the extent of CHD of VAD group was more severe than VAD absent group

Summary

Introduction

Visceral adiposity contributes to cardiometabolic risk, and visceral adiposity index (VAI) had significant correlation with visceral adiposity. We aimed to explore whether VAI was associated with cardiac structure and function and assess the impact of the cut-off points of VAI defining visceral adipose dysfunction (VAD) on the severity of coronary heart disease (CHD). In this regard, visceral adiposity has been found to play a key role in cardiometabolic risk [2]. To better understand the correlations between VAI and cardiac structure and function and the impact of the cut-off points of VAI defining VAD on the severity of CHD, we used simple anthropometric measures, echocardiography and coronary angiography and examined: first, whether diabetes and VAD aggravated the severity of coronary artery disease of CHD patients. We determined the correlations between VAI and cardiac structure and function

Objectives

Methods

Results

Discussion

Conclusion