Abstract
BackgroundThe effects of visceral adiposity on decreased lung function have drawn much attention. Recently, the visceral adiposity index (VAI) has been proposed as a visceral fat distribution and dysfunction marker. However, the relationship between the VAI and lung function has not been investigated. The objective of the study was to analyze the association between the VAI and lung function and evaluate the potential of VAI as a predictor of lung function.MethodsWe collected data from a population-based study of 1786 subjects aged 40 years or older. All subjects completed a questionnaire and underwent anthropometric measurements and laboratory tests. Linear and logistic regression models were developed to assess the association between the VAI and lung function.ResultsThe VAI was inversely related to FVC%predicted in men and negatively associated with both FVC%predicted and FEV1%predicted in women. In the linear regression analysis, the decrease in FVC%predicted associated with each 10% increase in the VAI was 1.127% in men and 1.943% in women; the decrease in FEV1%predicted associated with each 10%increase in the VAI was 0.663% in men and 1.738% in women. Further regression analysis revealed that the VAI was positively correlated with FVC and FEV1 impairment in women.ConclusionsWe were the first to show a clear correlation between the VAI and lung function impairment in the Chinese population. The VAI could be a simple and reliable approach in daily practice, and individuals, especially women with a high VAI, should receive additional screening and preventive interventions for respiratory disease.
Highlights
Impaired pulmonary function is a predictor of mortality related to various diseases independent of diagnosed lung disease and smoking status [1]
Since waist circumference (WC) is a great indicator of abdominal obesity, it is correlated with both subcutaneous fat and visceral fat, which contribute to the relationship between abdominal obesity and lung function, respectively [3,4,5,6]
After performing multivariate stepwise linear regression analysis, we found that visceral adiposity index (VAI) (β = − 0.098, 0.001) was only negatively and significantly correlated with forced vital capacity (FVC) %predicted in addition to WC and Systolic blood pressure (SBP) in women
Summary
Impaired pulmonary function is a predictor of mortality related to various diseases independent of diagnosed lung disease and smoking status [1]. There is less information on the determinants of lung function other than cigarette smoking in the general population. In a large-scale population-based study, abdominal obesity was the key determinant of the association between decreased lung function and metabolic syndrome, independent of major cardiovascular risk factors [2]. Since waist circumference (WC) is a great indicator of abdominal obesity, it is correlated with both subcutaneous fat and visceral fat, which contribute to the relationship between abdominal obesity and lung function, respectively [3,4,5,6]. The effects of visceral adiposity on decreased lung function have drawn much attention. The relationship between the VAI and lung function has not been investigated. The objective of the study was to analyze the association between the VAI and lung function and evaluate the potential of VAI as a predictor of lung function
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