Abstract
BackgroundVisceral adiposity index (VAI) and atherogenic index of plasma (AIP) are relatively new indicators for predicting non-communicable diseases (NCDs). Therefore, the present study was done to assess the association of AIP and VAI with risk of cardiovascular diseases (CVDs).MethodsThis cross-sectional study was conducted on 7,362 individuals aged between 35 and 65 years old participated in Ravansar non-communicable diseases (RaNCD) cohort study. AIP was calculated based on levels of triglyceride and high -density lipoprotein cholesterol (HDL-C). VAI was calculated using values of body mass index (BMI), waist circumference (WC), triglyceride, and HDL-C. Logistic regression models were used to assess the association of AIP and VAI with risk of CVDs.ResultsMean values of anthropometric indices, lipid profile, AIP, and VAI were significantly higher in patients with CVDs than individuals without CVDs (P < 0.001). Mean values of anthropometric indices, lipid profile, and NCDs including hypertension, dyslipidemia, diabetes, metabolic syndrome (MetS), and CVDs in the third tertile of AIP and VAI were significantly increased compared to the first tertile (P < 0.001). After adjusting confounding factors, risk of CVDs in the third tertile of AIP was (OR = 1.32, 95 % CI: 1.03, 1.69) significantly increased compared to the first tertile. Risk of CVDs in the third tertile of VAI was (OR = 1.48, 95 % CI: 1.12, 1.97) significantly increased compared to the first tertile.ConclusionsAccording to the findings, AIP and VAI were positively associated with risk of CVDs. Therefore, AIP and VAI can be useful in identifying high-risk subgroups of CVDs in general population.
Highlights
Visceral adiposity index (VAI) and atherogenic index of plasma (AIP) are relatively new indicators for predicting non-communicable diseases (NCDs)
Characteristics of the participants 7,362 subjects out of 10,047 participants of Ravansar non-communicable diseases (RaNCD) were eligible for data analysis
Findings of this study showed a positive association between AIP and VAI with risk of cardiovascular diseases (CVDs) in adults, and this association remained significant after adjusting for potential confounders
Summary
Visceral adiposity index (VAI) and atherogenic index of plasma (AIP) are relatively new indicators for predicting non-communicable diseases (NCDs). The present study was done to assess the association of AIP and VAI with risk of cardiovascular diseases (CVDs). Cardiovascular diseases (CVDs) are the main cause of death worldwide. 50 % of annual deaths and 50 % of deaths caused by non-communicable diseases (NCDs) are due to CVDs in Iran [2]. Obesity and dyslipidemia are the known risk factors for CVDs, which are preventable and changeable [3,4,5]. Their screening can be useful for prediction and early detection of CVDs in populations
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