Abstract
Infections with “high-risk” mucosal human papillomaviruses (HPVs) cause approximately 5% of all cancers worldwide. These include almost all cases of cervical carcinoma (a leading cause of cancer death in women), a large fraction of other anogenital tract cancers, and oropharyngeal tumors. For the last 30 years, my research has been focused on the molecular mechanisms by which HPVs contribute to cancer formation. In an article published some years ago, I posed the question of whether such behavior “represents relentless scientific curiosity or is simply a reflection of intellectual lethargy”. This short article attempts to convince readers that it is the former rather than the latter possibility.
Highlights
Infections with “high-risk” mucosal human papillomaviruses (HPVs) cause approximately 5% of all cancers worldwide
For the last 30 years, my research has been focused on the molecular mechanisms by which HPVs contribute to cancer formation
We discovered that E7 and E6 were carcinogens and that they contributed to oncogenesis at least in part by targeting the cellular retinoblastoma and p53 tumor suppressors, respectively
Summary
Infections with “high-risk” mucosal human papillomaviruses (HPVs) cause approximately 5% of all cancers worldwide. For the last 30 years, my research has been focused on the molecular mechanisms by which HPVs contribute to cancer formation. In an article published some years ago, I posed the question of whether such behavior “represents relentless scientific curiosity or is a reflection of intellectual lethargy”.
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