Abstract
The pathogenicity of two ecotropic viruses cloned from a Rauscher virus complex (RV), that had been passaged in the mouse, has been studied. One of the viruses, R-MuLV, gives rise to syncytia in the XC test (XC-positive), the other, R-XC − virus, does not (XCnegative). Both cloned viruses induce erythroblastosis and thymic lymphoma after inoculation into newborn NIH Swiss mice. Another clonal isolate of R-MuLV, from a stock which has been propagated in tissue culture, similarly induces both diseases when injected into newborn NIH Swiss mice. All R-MuLV and R-XC − induced splenic and thymic tumors produced, in addition to the injected virus, mink cell focus-inducing virus. This is consistent with the idea that MCF viruses are the actual (proximal) viruses causing the proliferative processes in the hematopoietic cells which lead to the different diseases. The finding that an R-MCF virus, which in most cases induces erythroblastosis, can also induce thymic lymphoma at a low frequency suggests that both diseases could be induced by the same MCF virus.
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