Abstract
RNA viruses are metastable macromolecular assemblies that sense their environment through dynamic breathing motions. Amide hydrogen/exchange mass spectrometry (HDXMS) is a powerful method to uncover dynamics of whole viral particles in solution. I will describe dynamics of viral surface regions and core ribonucleoprotein in two model viruses: Dengue and Turnip Crinkle Virus (TCV). We have identified a broad neutralizing antibody, C10 that induces altered ‘breathing’ dynamics in dengue viral particles and shows unique stoichiometry-specific responses.
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