Abstract

Several workers have shown that iron compounds greatly enhance the virulence of various bacteria in experimental animals as mice, rats and guinea-pigs. This virulence-enhancing effect has been demonstrated with Pasteurella pestis [1], Klebsiella pneumoniae [2, 3], Salmonella typhimurium [3], Listeria monocytogenes [4], Clostridium welchii [5–7], Pasteurella septica [6, 8–10], Escherichia coli [6, 11–13] and Pseudomonas aeruginosa [2, 14]. Various iron compounds, as ferric ammonium citrate (FAC), or sulfate and iron- containing substances as haematin hydrochloride, lysed red cells and purified haemoglobin [8, 11] proved to be equally active.

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