Abstract
Vibrio cholerae, the causative agent of epidemic cholera, must coordinate the expression of its virulence genes to produce disease. The most well defined virulence factors are the cholera toxin (CT) and the toxin co-regulated pilus (TCP), which are regulated by ToxR, TcpP and ToxT. ToxR and TcpP are inner-membrane-associated transcription factors that act cooperatively to activate transcription of ToxT, which in turn directly activates transcription of the genes encoding CT and TCP. During infection of the host, V. cholerae induces expression of ToxT and CT.Recently, Lee and collaborators devised a strategy to identify the genes involved in the activation of ctxA and toxT in vivo 1xSelection for in vivo regulators of bacterial virulence. Lee, S.H. et al. Proc. Natl. Acad. Sci. U. S. A. 2001; 98: 6889–6894Crossref | PubMed | Scopus (121)See all
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