Abstract
Virtual Screening of Indonesian Herbal Database as Adenosine A2A Antagonist using AutoDock and AutoDock Vina
Highlights
Parkinson’s disease is a chronic progressive neurodegenerative disorder
The aim of this study is to explore Indonesian herbal compounds as Adenosine A2A inhibitor using virtual screening method
In this study, virtual screening of Indonesian herbal database as Adenosine A2A inhibitor was done by AutoDock and AutoDock Vina and was validated by database from A Directory of Useful Decoys: Enhanced (DUD-E)
Summary
Parkinson’s disease is a chronic progressive neurodegenerative disorder. The main feature of Parkinson’s disease is the loss of dopaminergic neuron from subtantia nigra pars compacta (SNc) with Lewy body formation. Based on worldwide data analysis, the prevalence of Parkinson’s disease is 5.2 million people and high at the age above 40 years with the prevalence of men 1.8 times greater than woman. In Indonesia, as many as 1 in a million people suffer from Parkinson’s disease.[1]. The most common therapy for Parkinson’s disease is dopamine precursor, L-3, 4-dihydroxyphenylalanine (L-DOPA) with carbidopa as an initial treatment. In long term use it can lead to complications such as motor fluctuations,[2] dyskinesia,[3] and cognitive dysfunction.[4] a new treatment strategy is needed that aims to provide more effective dopaminergic stimulation to prevent motor complications.[5]
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