Abstract
One of the most striking marks of infection caused by the SARS-CoV-2 is the distinguishing heterogeneity of the clinical presentations in a population that varies from asymptomatic to severe forms. Pandemic proportion brings into the foreground the number of people with severe forms of the disease, putting aside the fact that a large portion of the population is an asymptomatic, making them silent carriers of the virus. Additional confusion is made by inconsistent data about the presence of the virus in the nasopharyngeal region and the manifestation of the disease symptoms. Different tissue distribution of virus in the body starting from guts, liver, muscles, kidney etc. without any signs of tissue destruction, opens up the possibility that individuals with negative results of PCR test in the nasopharyngeal swab may also be latent carriers of the infection. Overall clinical presentation of the disease is influenced by the initial protection gained through the accumulated "experience" collected from previous encountering of corona family and noncorona viruses, resulting in overlapping of the humoral and cellular immunity. Apart from this, unjustifiably neglected but very significant form of host defense against infection is disease tolerance based on cohabitation with pathogen. It is important to note that consequences of the disease tolerance in terms of pathological and epidemiological aspects are quite different then classical antiviral immune response. This work will elaborate the impact of virome on the course of infection at all stages taking into account both immune resistance, as an ability of the host immune system to eliminate pathogen, and disease tolerance, as a form of host defense with neutral to positive impact to pathogen load. Also, in accordance with the above mentioned, the potential of naturally occurring compounds to profile the course of infection and to support currently available protocols for COVID-19 treatment was discussed.
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