Abstract

Among the nucleic acids, the single-stranded RNA molecules have the highest potential to form a large variety of structures and to undergo quite different structural transitions. The determination of their structure and structural transitions is a prerequisite for understanding their function in replication, transcription, translation, and regulation. In many cases the problem of RNA structure is particularly difficult for in addition to the secondary structure formed by Watson-Crick base pairs and possibly wobble base pairs, a complicated tertiary structure exists which cannot be described by a few prototypes of interactions.

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