Abstract
A twenty-one year old woman who became markedly virilized during the eighth month of gestation is described. The virilizing syndrome was due to a mucinous cystadenoma of the ovary which contained stromal Leydig cells. A marked difference in plasma testosterone concentration between simultaneously obtained tumor-ovarian venous and peripheral venous plasma samples at surgery was demonstrated, indicating testosterone secretion by the neoplasm. Virilization regressed completely by the fifth postoperative month. The literature on virilization during pregnancy is reviewed. Evidence is presented which suggests that some ovarian tumors may modify the functional state of the stromal compartment, particularly under the gonadotropin stimulus of pregnancy, resulting in an over-production of androgenic steroids.
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