Abstract
Byssochlamys spectabilis (anamorph Paecilomyces variotii) strain 10536 was isolated as an endophyte from grapevine and investigated for its secondary metabolite production. Cultures of B. spectabilis yielded the known compound viriditin A (1) and its new derivative viriditin B (2), which showed pronounced cis–trans-amide isomerism. The previously unknown absolute configuration of C–2 and C–13 in 1 were assigned by Mosher’s method. Marfey’s method confirmed 2S stereochemistry after Jones oxidation and hydrolysis. A series of feeding experiments with [1-13C], [2-13C] and [1, 2-13C2]-acetate as well as [methyl-13C]-methionine indicated a polyketide biosynthetic pathway. Compound 1 showed weak cytotoxicity against the cell line KB3.1 with an IC50 = 30 µg/ml.
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