Abstract
BackgroundThe clinical course of Viridans streptococci (VS) peritonitis in patients undergoing peritoneal dialysis (PD) is rarely reported. This study examined the association of clinical factors with VS peritonitis.MethodsWe retrospectively reviewed clinical data from patients with VS peritonitis from March 1990 to February 2016 in a PD center in Taiwan and evaluated clinical profiles and treatment outcomes.ResultsA total of 109 episodes of VS peritonitis in 71 patients identified. Among these patients, 57 had mono-VS peritonitis and 14 had concurrent polymicrobial infections. The median time interval from PD initiation to the first VS peritonitis episode was 18 months (range, 0.6–144 months). Among clinical outcomes, most VS peritonitis episodes were completely cured regardless of a history of peritonitis. All episodes with catheter removal occurred in those without a history of recent antibiotic use.ConclusionVS peritonitis in patients undergoing PD typically has favorable treatment outcomes. Antibiotic therapy should be started promptly.
Highlights
The clinical course of Viridans streptococci (VS) peritonitis in patients undergoing peritoneal dialysis (PD) is rarely reported
Their medical notes were reviewed to retrieve the following information: demographics, primary kidney diseases, estimated glomerular filtration rate, baseline body mass index, time elapsed from PD initiation to the first onset of PD-related peritonitis, recent antibiotic exposure (≦2 weeks) and prior peritonitis, and antibiotic(s) to which the culprit VS and other culprit bacteria were susceptible. eGFR was calculated based on urine collected for 24 h, and was normalized to body surface area using the Du Bois formula and patient body weight [8]
A total of 109 VS peritonitis episodes were identified in 71 patients (57 with mono-VS peritonitis and 14 with mixed-VS peritonitis), accounting for 10.27% (109/1061) of the overall episodes of PD-related peritonitis during the study period
Summary
The clinical course of Viridans streptococci (VS) peritonitis in patients undergoing peritoneal dialysis (PD) is rarely reported. Peritoneal dialysis (PD)-related peritonitis is a common complication in patients undergoing regular PD. Clinical courses of PD-related peritonitis vary from mild to severe forms, depending on the causative organisms and clinical conditions. Mono-VS peritonitis in patients undergoing PD in general has a favorable outcome, little is known about the clinical outcomes of VS-included polymicrobial peritonitis (mixed-VS peritonitis) in this patient population.
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