Abstract
In this study, Liu et al. have investigated the inhibitory effects of hepatitis B viral X gene-coded protein (HBx) on circular RNA circSFMBT2 expression in host cells in connection to hepatocellular carcinoma (HCC) cell metastasis. The authors have delineated a novel mechanism to show how HBx lowers circSFMBT2 expression to upregulate miR-665 activity linked with miR-665 target gene TIMP3 downregulation and enhanced HCC metastasis.1 They also found that circSFMBT2 RNA acts as sponge for miR-665 in hepatic cells.
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