Abstract
Many infectious agents may invade the heart and initiate an inflammatory process. The virus appears to be a frequent offender, and its role in the production of both acute and chronic myocarditis is emphasized. The striking similarities, both clinically and pathologically, between chronic infectious myocarditis and a large group of unexplained myocardial diseases are stressed, and the possible relationships are discussed. The role of autoimmunity in the development of viral myocarditis is placed in current perspective. The treatment of the disease is at present symptomatic and supportive. Specific therapy awaits a better understanding of the mechanisms of injury. The consideration that infectious myocarditis has immune connotations, or that many instances of unexplained myocardial disease are related to old viral infections is conjectural and awaits further investigation.
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