Abstract
BackgroundA few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients.MethodsSixty-nine primary prostate carcinomas were analyzed for the presence of HPV, BKPyV and JCPyV using standard polymerase chain reaction protocols. In addition, when samples were positive for HPyV, large T antigen (TAg) transcripts were analyzed using reverse transcriptase PCR.ResultsHPV and JCPyV were not detected in any specimens (0/69, 0 %); whereas, BKPyV was detected in 6/69 PCas (8.7 %). We did not find a statistically significant association between the presence of BKPyV and age (p = 0.198) or Gleason score (p = 0.268). In addition, 2/6 (33 %) BKPyV positive specimens showed detectable levels of TAg transcripts.ConclusionsThere was no association between HPV or JCPyV presence and prostate cancer development. The presence of BKPyV in a small subset of prostate carcinomas in Chilean patients could indicate that this virus plays a potential role in prostate cancer development and requires further investigation.
Highlights
Prostate cancer (PCa) is the second most common cancer worldwide [1], and is common in industrialized countries
Human papillomavirus (HPV) and polyomaviruses (HPyV) are small non-enveloped DNA viruses that have been detected at variable frequencies in PCas worldwide
In this study we determined the presence of human papillomavirus (HPV), BKPyV and JCPyV in PCas in Chilean patients
Summary
Prostate cancer (PCa) is the second most common cancer worldwide [1], and is common in industrialized countries. Human papillomavirus (HPV) and polyomaviruses (HPyV) are small non-enveloped DNA viruses that have been detected at variable frequencies in PCas worldwide. The etiological role of these viruses has only been established in specific tumors. There is convincing evidence that Merkel cell polyomavirus (MCPyV) is the etiological agent of Merkel cell carcinomas [3]. A few viruses have been detected in prostate cancer, their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients
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