Abstract
Viruses are known to impact clinical status in patients with cystic fibrosis (CF); however their effects on the respiratory microbiome are unclear. The goal of our study is to assess changes in the lung microbiome of pediatric patients with CF during periods of wellness and exacerbation, with a focus on the impact of viral infection, using culture-dependent and independent techniques. Our hypothesis is that viruses impact the respiratory microbiome leading to worse clinical sequelae during exacerbation.
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