Abstract

Introduction. Viral infections during pregnancy have always been considered to cause complications and adverse events and birth defects during pregnancy. In particular, we do not have any therapeutic or preventive tools aimed at protecting the mother and fetus during the gestational period during pandemics. Methods. The studies were identified by using the PubMed database published until 30 April 2021. The search was performed by using the following keywords: viral infection, SARS-CoV-2, COVID-19, vaccine, pregnancy, gestational period, pandemics, vaccination, complication, adverse events, drugs. Results. It has been reported that viral infections are considered to cause complications and adverse events during pregnancy. In this regard, pregnancy is associated with higher mortality rates and complications during viral infections. In fact, maternal immunization represents a unique approach to protect newborns from several infectious diseases. Conclusion. European Board and College of Obstetrics and Gynecology (EBCOG) and International public health institutions (WHO, CDC) report the recommendations about the use of vaccines during pregnancy.

Highlights

  • Viral infections during pregnancy have always been considered to cause complications and adverse events and birth defects during pregnancy

  • The pregnant woman will undergo a series of immune changes that can increase the susceptibility of the mother to infectious diseases [45,46]

  • It is likely that SARS-CoV-2 vaccination could prevent tens of thousands of postoperative deaths linked to COVID-19, especially in particular situations such as pregnancy

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Summary

Introduction

Viral infections during pregnancy have always been considered to cause complications and adverse events and birth defects during pregnancy. It is conceivable that most pregnant patients infected with the COVID-19 virus have mild or moderate flu symptoms. More serious symptoms, such as pneumonia, seem to be more common in the elderly population or in subjects suffering from chronic diseases. Pregnant women are considered the most vulnerable, in particular in the first trimester during embryogenesis and for symptomatic patients. This is because, there are no data relating to greater risk, not all the potential effects that the virus could cause on the body of a pregnant woman are known. COVID 2021, 1 describe the therapeutic or preventive tools for the mother and fetus during the gestational period and, in particular during the COVID-19 pandemic

Methods
Pathogenesis of Viral Infections in Pregnancy
Viral Infection and Maternal Health
COVID-19 Virus Infection
Changes in the Respiratory System
Changes in the Immune System
ACE2 Expression Increased during Pregnancy
Effects of Viral Infection on the Fetus
Care of Pregnant Patients with COVID-19
Steroids
Azithromycin
Heparin
Interferon
Antivirals
Monoclonal Antibody Therapy
10. The Management of SARS-CoV-2 in Neonatal Intensive Care Units
11. SARS-CoV-2 Infection and Breastfeeding
12. Vaccine and Pregnancy
13. Conclusions
Findings
14. Take Home Messages
Full Text
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