Viral-host RNA-RNA interactions in SARS-CoV-2: study of MIR-760-3p interactions with the genome 3'-untranslated region

Abstract

The recent coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has marked the spread of a novel human coronavirus. SARS-CoV-2 is a member of the family Coronaviridae, a group of enveloped, positive-strand RNA viruses. Members of this family have highly conserved structural elements in their 5' and 3' untranslated regions (UTR), which are believed to have noncanonical functions. The details of the mechanisms by which it triggers observed severe symptoms in those infected are not clearly understood.