Abstract
The severity of hepatitis during pregnancy and the effect of hepatitis on pregnancy and the fetus have been evaluated in southern Iran. The prospective study group included 34 pregnant women. Hospital records of 95 women of childbearing age with hepatitis were also analyzed retrospectively. Of these, 27 were pregnant. Among this total of 61 pregnant women. there were 29 cases of fulminant hepatitis with 21 deaths. In the 68 nonpregnant women, 14 cases of fulminant hepatitis occurred with 12 deaths. This significantly increased frequency of fulminant hepatitis in pregnancy (P < 0.05) was indicative of a greater severity of hepatitis during pregnancy. Increased susceptibility to fulminant hepatitis was observed almost exclusively in the last trimester. Malnutrition and possibly hormonal changes of late pregnancy appeared to play a significant role in the pathogenesis of fulminant hepatitis in pregnancy. Hepatitis also had a deleterious effect on the outcome of pregnancy and the survival of the fetus including termination of pregnancy, prematurity, and fetal wastage, which were directly related to the severity of hepatitis.
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