Abstract
Viruses, especially rotaviruses, are the most important cause of diarrhoeal disease in children. Increasingly epidemics and sporadic cases of diarrhoeal disease in adults are recognized to be caused by astroviruses, caliciviruses and rotaviruses. Repeated infections with rotaviruses occur throughout an individual's lifetime but these are likely to be asymptomatic after the first two or three. Oral immunization with a tetravalent human-bovine reassortant rotavirus vaccine has been proved to be safe and effective in developed countries. However, rotavirus shows tremendous antigenic variability and we must have effective surveillance for the possible emergence of vaccine escape mutants.
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